Manganese homeostasis refers to the regulation of manganese levels within cells and tissues in order to maintain proper biological function. Manganese is an essential trace element that plays important roles in various cellular processes, including energy metabolism, antioxidant defense, and neurotransmitter synthesis. However, excessive manganese accumulation can be toxic and contribute to neurodegenerative diseases such as Parkinson's disease. Research on manganese homeostasis aims to understand the mechanisms by which cells regulate manganese uptake, storage, and excretion, as well as how disruptions in these processes may lead to health problems. This area of study is important for identifying potential therapeutic targets for diseases related to manganese dysregulation and developing strategies to prevent or treat manganese toxicity.